Enhancing lower respiratory tract infection diagnosis: implementation and clinical assessment of multiplex PCR-based and hybrid capture-based targeted next-generation sequencingResearch in context

Enhancing lower respiratory tract infection diagnosis: implementation and clinical assessment of multiplex PCR-based and hybrid capture-based targeted next-generation sequencingResearch in context

Summary: Background: Shotgun metagenomic next-generation sequencing (mNGS) is widely used to detect pathogens in bronchoalveolar lavage fluid (BALF). However, mNGS is complex and expensive. This study explored the feasibility of targeted next-generation sequencing (tNGS) in distinguishing lower res...

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Bibliographic Details
Main Authors: Yuyao Yin, Pengyuan Zhu, Yifan Guo, Yingzhen Li, Hongbin Chen, Jun Liu, Lingxiao Sun, Shuai Ma, Chaohui Hu, Hui Wang
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:EBioMedicine
Subjects:
Metagenomic next-generation sequencing
Targeted next-generation sequencing
Pathogen
Bronchoalveolar lavage fluid
Pneumonia
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424003438

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http://www.sciencedirect.com/science/article/pii/S2352396424003438

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