Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models: Implications for model selection and tiered modeling frameworks

Development and intercomparison of single and multicompartment physiologically-based toxicokinetic models: Implications for model selection and tiered modeling frameworks

This study describes the development and intercomparison of generic physiologically-based toxicokinetic (PBTK) models for humans comprised of internally consistent one-compartment (1Co-) and multi-compartment (MCo-) implementations (G-PBTK). The G-PBTK models were parameterized for an adult male (70...

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Bibliographic Details
Main Authors: James M. Armitage, Lauren Hughes, Alessandro Sangion, Jon A. Arnot
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Environment International
Subjects:
Chemical assessment
Toxicokinetics
Biotransformation
Modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412021001823

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http://www.sciencedirect.com/science/article/pii/S0160412021001823

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