Novel 3-Amino-6-chloro-7-(azol-2 or 5-yl)-1,1-dioxo-1,4,2-benzodithiazine Derivatives with Anticancer Activity: Synthesis and QSAR Study

Novel 3-Amino-6-chloro-7-(azol-2 or 5-yl)-1,1-dioxo-1,4,2-benzodithiazine Derivatives with Anticancer Activity: Synthesis and QSAR Study

A series of new 3-amino-6-chloro-7-(azol-2 or 5-yl)-1,1-dioxo-1,4,2-benzodithiazine derivatives 5a–j have been synthesized and evaluated in vitro for their antiproliferative activity at the U.S. National Cancer Institute. The most active compound 5h showed significant cytotoxic effects against ovari...

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Bibliographic Details
Main Authors: Aneta Pogorzelska, Jarosław Sławiński, Kamil Brożewicz, Szymon Ulenberg, Tomasz Bączek
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Molecules
Subjects:
1,4,2-benzodithiazines
sulfonamide
QSAR
anticancer activity
Online Access:http://www.mdpi.com/1420-3049/20/12/19821

Internet

http://www.mdpi.com/1420-3049/20/12/19821

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