The blood–brain barrier: Structure, regulation and drug delivery

Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and biopharmaceuticals have been impeded to ent...

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Bibliographic Details
Main Authors: Di Wu, Qi Chen, Xiaojie Chen, Feng Han, Zhong Chen, Yi Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01481-w