Effect of diphtheria toxin T-domain on endosomal pH

A key step in the mode of cytotoxic action of diphtheria toxin (DT) is the transfer of its catalytic domain (Cd) from endosomes into the cytosol. The main activity in this process is performed by the transport domain (Td), but the molecular mechanism of its action remains unknown. We have previously...

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Bibliographic Details
Main Authors: A. J. Labyntsev, N. V. Korotkevych, D. V. Kolybo, S. V. Komisarenko
Format: Article
Language:English
Published: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2015-08-01
Series:The Ukrainian Biochemical Journal
Subjects:
Online Access:http://ukrbiochemjournal.org/wp-content/uploads/2015/07/Labyntsev_4-15.pdf