Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller <i>Streptomyces</i> sp. CS113

Unearthing a Cryptic Biosynthetic Gene Cluster for the Piperazic Acid-Bearing Depsipeptide Diperamycin in the Ant-Dweller <i>Streptomyces</i> sp. CS113

Piperazic acid is a cyclic nonproteinogenic amino acid that contains a hydrazine N-N bond formed by a piperazate synthase (KtzT-like). This amino acid, found in bioactive natural products synthesized by non-ribosomal peptide synthetases (NRPSs), confers conformational constraint to peptides, an impo...

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Bibliographic Details
Main Authors: Coral García-Gutiérrez, Ignacio Pérez-Victoria, Ignacio Montero, Jorge Fernández-De la Hoz, Mónica G. Malmierca, Jesús Martín, José A. Salas, Carlos Olano, Fernando Reyes, Carmen Méndez
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Streptomyces</i>
diperamycin
piperazate
depsipeptide
azinothricin
N-N bond
Online Access:https://www.mdpi.com/1422-0067/25/4/2347

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https://www.mdpi.com/1422-0067/25/4/2347

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