Heterogeneity and Differentiation Trajectories of Infiltrating CD8+ T Cells in Lung Adenocarcinoma

Heterogeneity and Differentiation Trajectories of Infiltrating CD8+ T Cells in Lung Adenocarcinoma

CD8+ T cells infiltrating the tumor microenvironment (TME) of lung adenocarcinoma (LUAD) are critical for establishing antitumor immunity. Nevertheless, the global landscape of their numbers, functional status, and differentiation trajectories remains unclear. In the single-cell RNA-sequencing (scRN...

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Bibliographic Details
Main Authors: Xiaojie Song, Guanghui Zhao, Guangqiang Wang, Haidong Gao
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
lung adenocarcinoma
CD8+ T cells
heterogeneity
differentiation trajectory
functional exhaustion
Online Access:https://www.mdpi.com/2072-6694/14/21/5183

Internet

https://www.mdpi.com/2072-6694/14/21/5183

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