Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions

Polyamines Counteract Carbonate-Driven Proteasome Stalling in Alkaline Conditions

Cancer cells tend to increase intracellular pH and, at the same time, are known to intensively produce and uptake polyamines such as spermine. Here, we show that various amines, including biogenic polyamines, boost the activity of proteasomes in a dose-dependent manner. Proteasome activity in the cl...

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Bibliographic Details
Main Authors: Anna A. Kudriaeva, George A. Saratov, Alena N. Kaminskaya, Vasiliy I. Vladimirov, Petro Yu Barzilovich, Alexey A. Belogurov
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomolecules
Subjects:
proteasome
polyamine
spermine
intracellular alkalization
activation
carbonate
Online Access:https://www.mdpi.com/2218-273X/10/12/1597

Internet

https://www.mdpi.com/2218-273X/10/12/1597

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