ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells

ALDH1A3 upregulation and spontaneous metastasis formation is associated with acquired chemoresistance in colorectal cancer cells

Abstract Background Efficiency of colorectal carcinoma treatment by chemotherapy is diminished as the resistance develops over time in patients. The same holds true for 5-fluorouracil, the drug used in first line chemotherapy of colorectal carcinoma. Methods Chemoresistant derivative of HT-29 cells...

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Bibliographic Details
Main Authors: Erika Durinikova, Zuzana Kozovska, Martina Poturnajova, Jana Plava, Zuzana Cierna, Andrea Babelova, Roman Bohovic, Silvia Schmidtova, Miroslav Tomas, Lucia Kucerova, Miroslava Matuskova
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Cancer
Subjects:
5-fluorouracil
Chemoresistance
Colorectal cancer
Aldehyde dehydrogenase
Metastasis
Online Access:http://link.springer.com/article/10.1186/s12885-018-4758-y

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http://link.springer.com/article/10.1186/s12885-018-4758-y

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