Polyethyleneimine (PEI) mediated siRNA gene silencing in the Schistosoma mansoni snail host, Biomphalaria glabrata.

An in vivo, non-invasive technique for gene silencing by RNA interference (RNAi) in the snail, Biomphalaria glabrata, has been developed using cationic polymer polyethyleneimine (PEI) mediated delivery of long double-stranded (ds) and small interfering (si) RNA. Cellular delivery was evaluated and o...

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Bibliographic Details
Main Authors: Matty Knight, Andre Miller, Yijia Liu, Puthupparampil Scaria, Martin Woodle, Wannaporn Ittiprasert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-07-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3134429?pdf=render