Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid

Astrocytic scar restricting glioblastoma via glutamate–MAO-B activity in glioblastoma-microglia assembloid

Abstract Background Glial scar formation is a reactive glial response confining injured regions in a central nervous system. However, it remains challenging to identify key factors formulating glial scar in response to glioblastoma (GBM) due to complex glia-GBM crosstalk. Methods Here, we constructe...

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Bibliographic Details
Main Authors: Yen N. Diep, Hee Jung Park, Joon-Ho Kwon, Minh Tran, Hae Young Ko, Hanhee Jo, Jisu Kim, Jee-In Chung, Tai Young Kim, Dongwoo Kim, Jong Hee Chang, You Jung Kang, C. Justin Lee, Mijin Yun, Hansang Cho
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2023-07-01
Series:Biomaterials Research
Subjects:
Glial scar formation
MAO-B
Glutamate
Glioblastoma
Microglia
Assembloid
Online Access:https://doi.org/10.1186/s40824-023-00408-4

Internet

https://doi.org/10.1186/s40824-023-00408-4

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