mTORC1 hyperactivation and resultant suppression of macroautophagy contribute to the induction of cardiomyocyte necroptosis by catecholamine surges

mTORC1 hyperactivation and resultant suppression of macroautophagy contribute to the induction of cardiomyocyte necroptosis by catecholamine surges

Abstract Previous studies revealed a controversial role of mechanistic target of rapamycin complex 1 (mTORC1) and mTORC1‐regulated macroautophagy in isoproterenol (ISO)‐induced cardiac injury. Here we investigated the role of mTORC1 and potential underlying mechanisms in ISO‐induced cardiomyocyte ne...

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Bibliographic Details
Main Authors: Mingqi Cai, Penglong Wu, Wei Ni, Dong Huang, Xuejun Wang
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Physiological Reports
Subjects:
catecholamine
isoproterenol
macroautophagy
mTORC1
necroptosis
Online Access:https://doi.org/10.14814/phy2.15966

Internet

https://doi.org/10.14814/phy2.15966

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