Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes

GWAS have so far identified 129 loci associated with type 2 diabetes (T2D). Here, the authors meta-analyse three large T2D GWA studies which uncovers 42 additional loci, further prioritize 33 functional genes using eQTL and mQTL data and propose regulatory mechanisms for three putative T2D genes.

Bibliographic Details
Main Authors: Angli Xue, Yang Wu, Zhihong Zhu, Futao Zhang, Kathryn E. Kemper, Zhili Zheng, Loic Yengo, Luke R. Lloyd-Jones, Julia Sidorenko, Yeda Wu, eQTLGen Consortium, Allan F. McRae, Peter M. Visscher, Jian Zeng, Jian Yang
Format: Article
Language:English
Published: Nature Portfolio 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04951-w

Internet

https://doi.org/10.1038/s41467-018-04951-w

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