WT-PE: Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing

WT-PE: Prime editing with nuclease wild-type Cas9 enables versatile large-scale genome editing

Abstract Large scale genomic aberrations including duplication, deletion, translocation, and other structural changes are the cause of a subtype of hereditary genetic disorders and contribute to onset or progress of cancer. The current prime editor, PE2, consisting of Cas9-nickase and reverse transc...

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Bibliographic Details
Main Authors: Rui Tao, Yanhong Wang, Yun Hu, Yaoge Jiao, Lifang Zhou, Lurong Jiang, Li Li, Xingyu He, Min Li, Yamei Yu, Qiang Chen, Shaohua Yao
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-00936-w

Internet

https://doi.org/10.1038/s41392-022-00936-w

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