Autophagy-lysosomal pathway impairment and cathepsin dysregulation in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by neuronal loss, attributed to amyloid-beta (Aβ) aggregation and accumulation. The autophagy-lysosomal pathway, including cathepsins B and D, is crucial for protein degradation and clearance, but it is impaired in some diseases. This review summarizes curre...

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Bibliographic Details
Main Authors: Alquiandra Stefani Ferreira Mançano, Juliana Guanaes Pina, Bruna Rojas Froes, Juliana Mozer Sciani
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1490275/full