Paracrine Factors of Stressed Peripheral Blood Mononuclear Cells Activate Proangiogenic and Anti-Proteolytic Processes in Whole Blood Cells and Protect the Endothelial Barrier

Paracrine Factors of Stressed Peripheral Blood Mononuclear Cells Activate Proangiogenic and Anti-Proteolytic Processes in Whole Blood Cells and Protect the Endothelial Barrier

Tissue-regenerative properties have been attributed to secreted paracrine factors derived from stem cells and other cell types. In particular, the secretome of γ-irradiated peripheral blood mononuclear cells (PBMCsec) has been shown to possess high tissue-regenerative and proangiogenic capacities in...

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Bibliographic Details
Main Authors: Dragan Copic, Martin Direder, Klaudia Schossleitner, Maria Laggner, Katharina Klas, Daniel Bormann, Hendrik Jan Ankersmit, Michael Mildner
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
regenerative medicine
cell-free secretomes
paracrine factors
single-cell RNA sequencing
serine protease inhibitor
endothelial barrier
Online Access:https://www.mdpi.com/1999-4923/14/8/1600

Internet

https://www.mdpi.com/1999-4923/14/8/1600

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