Neglog: Homology-Based Negative Data Sampling Method for Genome-Scale Reconstruction of Human Protein–Protein Interaction Networks

Neglog: Homology-Based Negative Data Sampling Method for Genome-Scale Reconstruction of Human Protein–Protein Interaction Networks

Rapid reconstruction of genome-scale protein–protein interaction (PPI) networks is instrumental in understanding the cellular processes and disease pathogenesis and drug reactions. However, lack of experimentally verified negative data (i.e., pairs of proteins that do not interact) is still a major...

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Bibliographic Details
Main Authors: Suyu Mei, Kun Zhang
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
protein–protein interaction
paralog/ortholog
negative data sampling
machine learning
l<sub>2</sub>-regularized logistic regression
Online Access:https://www.mdpi.com/1422-0067/20/20/5075

Internet

https://www.mdpi.com/1422-0067/20/20/5075

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