Application of multiplex amplicon deep-sequencing (MAD-seq) to screen for putative drug resistance markers in the Necator americanus isotype-1 β-tubulin gene

Application of multiplex amplicon deep-sequencing (MAD-seq) to screen for putative drug resistance markers in the Necator americanus isotype-1 β-tubulin gene

Abstract Global control of hookworm infections relies on periodic Mass Drug Administration of benzimidazole drugs to high-risk groups, regardless of infection status. Mutations in the isotype-1 β-tubulin gene have been identified in veterinary nematodes, resulting in structural changes and reduced d...

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Bibliographic Details
Main Authors: Santosh George, Peter Suwondo, Jewelna Akorli, Joseph Otchere, Lisa M. Harrison, Kaya Bilguvar, James R. Knight, Debbie Humphries, Michael D. Wilson, Adalgisa Caccone, Michael Cappello
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15718-1

Internet

https://doi.org/10.1038/s41598-022-15718-1

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