Microfluidic devices as model platforms of CNS injury-ischemia to study axonal regeneration by regulating mitochondrial transport and bioenergetic metabolism

Microfluidic devices as model platforms of CNS injury-ischemia to study axonal regeneration by regulating mitochondrial transport and bioenergetic metabolism

Abstract Central nervous system (CNS) neurons typically fail to regenerate their axons after injury leading to neurological impairment. Axonal regeneration is a highly energy-demanding cellular program that requires local mitochondria to supply most energy within injured axons. Recent emerging lines...

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Bibliographic Details
Main Authors: Ning Huang, Zu-Hang Sheng
Format: Article
Language:English
Published: SpringerOpen 2022-10-01
Series:Cell Regeneration
Subjects:
Microfluidic device
Axon injury
Ischemia
Axon regeneration
Mitochondrial transport
Axonal bioenergetics
Online Access:https://doi.org/10.1186/s13619-022-00138-3

Internet

https://doi.org/10.1186/s13619-022-00138-3

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