Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine–1,5-Benzodiazepine Hybrids

Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine–1,5-Benzodiazepine Hybrids

Diterpenoid alkaloids, originating from the amination of natural tetracyclic diterpenes, have long interested scientists due to their medicinal uses and infamous toxicity which has limited the clinical application of the native compound. Alkaloid lappaconitine extracted from various <i>Aconitu...

Full description

Bibliographic Details
Main Authors: Kirill P. Cheremnykh, Arkadiy O. Bryzgalov, Dmitry S. Baev, Sergey A. Borisov, Yulia S. Sotnikova, Victor A. Savelyev, Tatyana G. Tolstikova, Shamansur S. Sagdullaev, Elvira E. Shults
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Molecules
Subjects:
diterpenoid alkaloids
lappaconitine
alkynyl ketones
Sonogashira coupling
cyclocondensation
1,5-benzodiazepines
Online Access:https://www.mdpi.com/1420-3049/28/10/4234

Internet

https://www.mdpi.com/1420-3049/28/10/4234

Similar Items