Preparation and Evaluation of the Cytoprotective Activity of Micelles with DSPE-PEG-C60 as a Carrier Against Doxorubicin-Induced Cytotoxicity

Preparation and Evaluation of the Cytoprotective Activity of Micelles with DSPE-PEG-C60 as a Carrier Against Doxorubicin-Induced Cytotoxicity

To deliver doxorubicin (DOX) with enhanced efficacy and safety in vivo, fullerenol-modified micelles were prepared with the amphiphilic polymer DSPE-PEG-C60 as a carrier, which was synthesized by linking C60(OH)22 with DSPE-PEG-NH2. Studies of its particle size, PDI, zeta potential, and encapsulatio...

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Bibliographic Details
Main Authors: Beihua Xu, Zhongpeng Ding, Ying Hu, Ting Zhang, Senlin Shi, Guangmao Yu, Xuchen Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
doxorubicin
DSPE-PEG-C60
micelles
cancer
apoptosis
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.952800/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.952800/full

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