Proteomic Identification of Potential Target Proteins of Cathepsin W for Its Development as a Drug Target for Influenza

ABSTRACT Influenza A virus (IAV) coopts numerous host factors for efficient replication. The cysteine protease cathepsin W (CTSW) has been identified as one host factor required for IAV entry, specifically for the escape of IAVs from late endosomes. However, the substrate specificity of CTSW and the...

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Bibliographic Details
Main Authors: Sira C. Günther, Carles Martínez-Romero, Milagros Sempere Borau, Christine T. N. Pham, Adolfo García-Sastre, Silke Stertz
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00921-22