5‐Lipoxygenase Gene Variants Are Not Associated With Atherosclerosis or Incident Coronary Heart Disease in the Multi‐Ethnic Study of Atherosclerosis Cohort

BackgroundThe arachidonate 5‐lipoxygenase enzyme plays a crucial role in mediating inflammation to maintain homeostasis, yet certain allelic variants of the 5‐lipoxygenase gene, ALOX5, may increase risk of atherosclerosis and coronary heart disease (CHD). Further, relations between ALOX5 and disease...

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Bibliographic Details
Main Authors: Michael Y. Tsai, Jing Cao, Brian T. Steffen, Natalie L. Weir, Stephen S. Rich, Shuang Liang, Weihua Guan
Format: Article
Language:English
Published: Wiley 2016-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.115.002814