Cell surface-localized CsgF condensate is a gatekeeper in bacterial curli subunit secretion

Abstract Curli are functional amyloids present on the outer membrane of E. coli. CsgF is required for the proper assembly of curli. Here, we found that the CsgF phase separates in vitro and that the ability of CsgF variants to phase-separate is tightly correlated with CsgF function during curli biog...

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Bibliographic Details
Main Authors: Hema M. Swasthi, Joseph L. Basalla, Claire E. Dudley, Anthony G. Vecchiarelli, Matthew R. Chapman
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38089-1