Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

Protective paraspeckle hyper-assembly downstream of TDP-43 loss of function in amyotrophic lateral sclerosis

Abstract Background Paraspeckles are subnuclear bodies assembled on a long non-coding RNA (lncRNA) NEAT1. Their enhanced formation in spinal neurons of sporadic amyotrophic lateral sclerosis (ALS) patients has been reported but underlying mechanisms are unknown. The majority of ALS cases are charact...

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Bibliographic Details
Main Authors: Tatyana A. Shelkovnikova, Michail S. Kukharsky, Haiyan An, Pasquale Dimasi, Svetlana Alexeeva, Osman Shabir, Paul R. Heath, Vladimir L. Buchman
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Molecular Neurodegeneration
Subjects:
ALS
TDP-43
Paraspeckle
NEAT1
Online Access:http://link.springer.com/article/10.1186/s13024-018-0263-7

Internet

http://link.springer.com/article/10.1186/s13024-018-0263-7

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