Inhibition of USP14 suppresses ferroptosis and inflammation in LPS-induced goat mammary epithelial cells through ubiquitylating the IL-6 protein

Abstract Background Ferroptosis, a novel manner of cell death depended on iron ion, contributed to goat mammary epithelial cell dysfunction. Interleukin-6 (IL-6) is a major pro-inflammatory factor during many inflammation-related diseases including mastitis, and a quite recently identified ferroptos...

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Bibliographic Details
Main Authors: Guangqin Zhu, Shaopu Sui, Fengyun Shi, Qinglin Wang
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Hereditas
Subjects:
Online Access:https://doi.org/10.1186/s41065-022-00235-y