Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms

Severity of Peripheral Infection Differentially Affects Brain Functions in Mice via Microglia-Dependent and -Independent Mechanisms

Peripheral infection induces inflammation in peripheral tissues and the brain, impacting brain function. Glial cells are key players in this process. However, the effects of peripheral infection on glial activation and brain function remain unknown. Here, we showed that varying degrees of peripheral...

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Bibliographic Details
Main Authors: Yen-Phung Le, Kozo Saito, Bijay Parajuli, Kent Sakai, Yuto Kubota, Miho Miyakawa, Youichi Shinozaki, Eiji Shigetomi, Schuichi Koizumi
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
microglia
macrophage
ischemic tolerance
middle cerebral artery occlusion (MCAO)
lipopolysaccharide (LPS)
RNA sequencing
Online Access:https://www.mdpi.com/1422-0067/24/24/17597

Internet

https://www.mdpi.com/1422-0067/24/24/17597

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