Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages

Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages

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Summary: It is widely assumed that all normal somatic cells can equally perform homologous recombination (HR) and non-homologous end joining in the DNA damage response (DDR). Here, we show that the DDR in normal mammary gland inherently depends on the epithelial cell lineage identity. Bioinformatics...

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Bibliographic Details
Main Authors: Hyeyeon Kim, Kazeera Aliar, Pirashaanthy Tharmapalan, Curtis W. McCloskey, Abhijith Kuttanamkuzhi, Barbara T. Grünwald, Luis Palomero, Mathepan J. Mahendralingam, Matthew Waas, Arvind S. Mer, Mitchell J. Elliott, Bowen Zhang, Khalid N. Al-Zahrani, Ellen R. Langille, Michael Parsons, Swami Narala, Stefan Hofer, Paul D. Waterhouse, Razqallah Hakem, Benjamin Haibe-Kains, Thomas Kislinger, Daniel Schramek, David W. Cescon, Miquel A. Pujana, Hal K. Berman, Rama Khokha
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723012688

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http://www.sciencedirect.com/science/article/pii/S2211124723012688

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