Functional domains of the FSHD-associated DUX4 protein

Functional domains of the FSHD-associated DUX4 protein

Aberrant expression of the full-length isoform of DUX4 (DUX4-FL) appears to underlie pathogenesis in facioscapulohumeral muscular dystrophy (FSHD). DUX4-FL is a transcription factor and ectopic expression of DUX4-FL is toxic to most cells. Previous studies showed that DUX4-FL-induced pathology requi...

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Bibliographic Details
Main Authors: Hiroaki Mitsuhashi, Satoshi Ishimaru, Sachiko Homma, Bryant Yu, Yuki Honma, Mary Lou Beermann, Jeffrey Boone Miller
Format: Article
Language:English
Published: The Company of Biologists 2018-04-01
Series:Biology Open
Subjects:
DUX4
Facioscapulohumeral dystrophy
Homeodomains
Muscular dystrophy
Skeletal muscle
Transactivation domain
Online Access:http://bio.biologists.org/content/7/4/bio033977

Internet

http://bio.biologists.org/content/7/4/bio033977

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