Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats

Macrocyclic MR contrast agents: evaluation of multiple-organ gadolinium retention in healthy rats

Abstract Objectives The purpose of this study was to compare Gd levels in rat tissues after cumulative exposure to four commercially available macrocyclic gadolinium-based contrast agents (GBCAs). Methods Sixty-five male Sprague-Dawley rats were randomized to four exposure groups (n = 15 per group)...

Full description

Bibliographic Details
Main Authors: Simona Bussi, Alessandra Coppo, Roberto Celeste, Antonello Fanizzi, Alberto Fringuello Mingo, Andrea Ferraris, Catherine Botteron, Miles A. Kirchin, Fabio Tedoldi, Federico Maisano
Format: Article
Language:English
Published: SpringerOpen 2020-02-01
Series:Insights into Imaging
Subjects:
Contrast media
Magnetic resonance imaging
Gadolinium
Pharmacokinetics
Histology
Rats
Online Access:https://doi.org/10.1186/s13244-019-0824-5

Internet

https://doi.org/10.1186/s13244-019-0824-5

Similar Items