Impacts of NaHCO<sub>3</sub> on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO<sub>3</sub>-Responsive versus NaHCO<sub>3</sub>-Non-Responsive Phenotypes

Impacts of NaHCO<sub>3</sub> on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO<sub>3</sub>-Responsive versus NaHCO<sub>3</sub>-Non-Responsive Phenotypes

Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) regulates resistance to β-lactams via preferential production of an alternative penicillin-binding protein (PBP), PBP2a. PBP2a binds many β-lactam antibiotics with less affinity than PBPs which are predominant in methicillin-susce...

Full description

Bibliographic Details
Main Authors: Selvi C. Ersoy, Liana C. Chan, Michael R. Yeaman, Henry F. Chambers, Richard A. Proctor, Kevin C. Ludwig, Tanja Schneider, Adhar C. Manna, Ambrose Cheung, Arnold S. Bayer
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Antibiotics
Subjects:
penicillin-binding proteins
sodium bicarbonate
β-lactams
methicillin-resistant <i>Staphylococcus aureus</i>
Online Access:https://www.mdpi.com/2079-6382/11/4/462

Internet

https://www.mdpi.com/2079-6382/11/4/462

Similar Items