Identification of New <i>N</i>-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors

Identification of New <i>N</i>-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors

Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) have been considered target enzymes of depression and neurodegenerative diseases, including Alzheimer’s disease (AD). In this study, seventeen <i>N</i>-methyl-piperazine chalcones were synthesized,...

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Bibliographic Details
Main Authors: Ashraf K. El-Damasy, Jong Eun Park, Hyun Ji Kim, Jinhyuk Lee, Eun-Kyoung Bang, Hoon Kim, Gyochang Keum
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceuticals
Subjects:
<i>N</i>-methyl-piperazine chalcones
monoamine oxidase
cholinesterase
kinetic study
docking simulation
Online Access:https://www.mdpi.com/1424-8247/16/1/83

Internet

https://www.mdpi.com/1424-8247/16/1/83

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