Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells

Inhibition of Notch pathway enhances the anti-tumor effect of docetaxel in prostate cancer stem-like cells

Abstract Background Prostate cancer stem-like cells (PCSCs) likely participate in tumor progression and recurrence and demonstrate resistance to chemotherapy. The Notch pathway plays a role in the maintenance of the stemness in PCSCs. This study aimed to investigate the efficacy of Notch signaling i...

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Bibliographic Details
Main Authors: Lei Wang, Hao Zi, Yi Luo, Tongzu Liu, Hang Zheng, Conghua Xie, Xinghuan Wang, Xing Huang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Subjects:
Prostate cancer
Cancer stem cells
Notch
γ-Secretase inhibitor
Docetaxel resistance
Online Access:http://link.springer.com/article/10.1186/s13287-020-01773-w

Internet

http://link.springer.com/article/10.1186/s13287-020-01773-w

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