Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon

Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon

The present work aimed to compare the small, neutral and monoaromatic oxime, isatin-3-oxime (isatin-O), to the commercial ones, pralidoxime (2-PAM) and obidoxime, in a search for a new potential reactivator for acetylcholinesterase (AChE) inhibited by the pesticide paraoxon (AChE/POX) as well as a n...

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Bibliographic Details
Main Authors: Reuel L. de Paula, Joyce S. F. D. de Almeida, Samir F. A. Cavalcante, Arlan S. Gonçalves, Alessandro B. C. Simas, Tanos C. C. Franca, Martin Valis, Kamil Kuca, Eugenie Nepovimova, José M. Granjeiro
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Molecules
Subjects:
acetylcholinesterase
neutral oxime
molecular modeling
multicriteria decision making
TOPSIS-AHP
Ellman’s method
Online Access:https://www.mdpi.com/1420-3049/23/11/2954

Internet

https://www.mdpi.com/1420-3049/23/11/2954

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