Sequence – dynamics – function relationships in protein tyrosine phosphatases

Sequence – dynamics – function relationships in protein tyrosine phosphatases

Protein tyrosine phosphatases (PTPs) are crucial regulators of cellular signaling. Their activity is regulated by the motion of a conserved loop, the WPD-loop, from a catalytically inactive open to a catalytically active closed conformation. WPD-loop motion optimally positions a catalytically critic...

Full description

Bibliographic Details
Main Authors: Rory M. Crean, Marina Corbella, Ana R. Calixto, Alvan C. Hengge, Shina C. L. Kamerlin
Format: Article
Language:English
Published: Cambridge University Press 2024-01-01
Series:QRB Discovery
Subjects:
empirical valence bond
enzyme evolution
loop dynamics
molecular simulations
protein tyrosine phosphatases
Online Access:https://www.cambridge.org/core/product/identifier/S2633289224000036/type/journal_article

Internet

https://www.cambridge.org/core/product/identifier/S2633289224000036/type/journal_article

Similar Items