Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer.

Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer.

Deregulation of canonical Wnt/CTNNB1 (beta-catenin) pathway is one of the earliest events in the pathogenesis of colon cancer. Mutations in APC or CTNNB1 are highly frequent in colon cancer and cause aberrant stabilization of CTNNB1, which activates the transcription of Wnt target genes by binding t...

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Bibliographic Details
Main Authors: Kazuhide Watanabe, Jacob Biesinger, Michael L Salmans, Brian S Roberts, William T Arthur, Michele Cleary, Bogi Andersen, Xiaohui Xie, Xing Dai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3961325?pdf=render

Internet

http://europepmc.org/articles/PMC3961325?pdf=render

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