Identification of prognostic cancer-associated fibroblast markers in luminal breast cancer using weighted gene co-expression network analysis

Identification of prognostic cancer-associated fibroblast markers in luminal breast cancer using weighted gene co-expression network analysis

BackgroundCancer-associated fibroblasts (CAFs) play a pivotal role in cancer progression and are known to mediate endocrine and chemotherapy resistance through paracrine signaling. Additionally, they directly influence the expression and growth dependence of ER in Luminal breast cancer (LBC). This s...

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Bibliographic Details
Main Authors: An Xu, Xiang-Nan Xu, Zhou Luo, Xiao Huang, Rong-Quan Gong, De-Yuan Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Oncology
Subjects:
luminal breast cancer (LBC)
cancer-associated fibroblasts (CAFs)
weighted gene co-expression network analysis (WGCNA)
prognostic CAF markers
anti-CAF therapeutic approach
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1191660/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1191660/full

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