Dependence of human cell survival and proliferation on the CASP3 prodomain

Abstract Mechanisms that regulate cell survival and proliferation are important for both the development and homeostasis of normal tissue, and as well as for the emergence and expansion of malignant cell populations. Caspase-3 (CASP3) has long been recognized for its proteolytic role in orchestratin...

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Bibliographic Details
Main Authors: Ebrahim Eskandari, Gian Luca Negri, Susanna Tan, Margarita E. MacAldaz, Shengsen Ding, Justin Long, Karina Nielsen, Sandra E. Spencer, Gregg B. Morin, Connie J. Eaves
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-01826-6