Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: Role of uric acid accumulation in gemcitabine-induced MICA/B expression

Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: Role of uric acid accumulation in gemcitabine-induced MICA/B expression

<p>Abstract</p> <p>Background</p> <p>Major histocompatibility complex class I-related chain A and B (MICA/B) are two stress-inducible ligands that bind the immunoreceptor NKG2D and play an important role in mediating the cyotoxicity of NK and T cells. In this study, we...

Full description

Bibliographic Details
Main Authors: Kaufman Howard L, Gattuso Paolo, Spies Thomas, Groh Veronika, Rao Geetha S, Xu Xiulong, Plate Janet, Prinz Richard A
Format: Article
Language:English
Published: BMC 2011-05-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
MICA/B
Gemcitabine
Uric acid
Allopurinol
DNA damage
Online Access:http://www.biomedcentral.com/1471-2407/11/194

Internet

http://www.biomedcentral.com/1471-2407/11/194

Similar Items