Over 2000-Fold Increased Production of the Leaderless Bacteriocin Garvicin KS by Increasing Gene Dose and Optimization of Culture Conditions

Over 2000-Fold Increased Production of the Leaderless Bacteriocin Garvicin KS by Increasing Gene Dose and Optimization of Culture Conditions

The leaderless bacteriocin Garvicin KS (GarKS) is a potent antimicrobial, being active against a wide range of important pathogens. GarKS production by the native producer Lactococcus garvieae KS1546 is, however, relatively low (80 BU/ml) under standard laboratory growth conditions (batch culture in...

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Bibliographic Details
Main Authors: Amar A. Telke, Kirill V. Ovchinnikov, Kiira S. Vuoristo, Geir Mathiesen, Tage Thorstensen, Dzung B. Diep
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Microbiology
Subjects:
garvicin KS
leaderless bacteriocins
bacteriocin production
antimicrobial production
lactic acid bacteria
Lactococcus garviae
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00389/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00389/full

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