Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC

Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC

Abstract Halogenation of pyrrole requires strong electrophilic reagents and often leads to undesired polyhalogenated products. Biocatalytic halogenation is a highly attractive approach given its chemoselectivity and benign reaction conditions. While there are several reports of enzymatic phenol and...

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Bibliographic Details
Main Authors: GuangRong Peh, Terence Tay, Lee Ling Tan, Elaine Tiong, Jiawu Bi, Yi Ling Goh, Suming Ye, Fu Lin, Cheryl Jia Xin Tan, Yong Zi Tan, Joel Wong, Huimin Zhao, Fong Tian Wong, Ee Lui Ang, Yee Hwee Lim
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-023-01083-1

Internet

https://doi.org/10.1038/s42004-023-01083-1

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