Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers

Comparison of pharmacokinetics and safety between CE-fosphenytoin sodium, fosphenytoin sodium, and phenytoin sodium after intravenous and intramuscular administration in healthy volunteers

Background: Captisol®-enabled-fosphenytoin sodium (CE-fosphenytoin sodium) injection is a modified formulation of fosphenytoin sodium.Objective: We aim to compare the intravenous and intramuscular bioavailability and safety between CE-fosphenytoin sodium, fosphenytoin sodium (Cerebyx®), and phenytoi...

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Bibliographic Details
Main Authors: Xiaojiao Li, Min Wu, Jixuan Sun, Weili Jin, Lei Han, Jia Xu, Jingrui Liu, Hong Zhang, Jing Wang, Daidi Wang, Hanyi Zhang, Qing Zhang, Nini Liu, Yanhua Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
pharmacokinetics
safety
CE-fosphenytoin sodium
fosphenytoin sodium
healthy volunteers
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1204075/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1204075/full

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