Achieving optimal growth through product feedback inhibition in metabolism.

Recent evidence suggests that the metabolism of some organisms, such as Escherichia coli, is remarkably efficient, producing close to the maximum amount of biomass per unit of nutrient consumed. This observation raises the question of what regulatory mechanisms enable such efficiency. Here, we propo...

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Bibliographic Details
Main Authors: Sidhartha Goyal, Jie Yuan, Thomas Chen, Joshua D Rabinowitz, Ned S Wingreen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2880561?pdf=render