The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer

Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals,...

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Bibliographic Details
Main Authors: Derek J. Erstad, Andrew M. Tager, Yujin Hoshida, Bryan C. Fuchs
Format: Article
Language:English
Published: Taylor & Francis Group 2017-05-01
Series:Molecular & Cellular Oncology
Subjects:
atx
chemoprevention
cirrhosis
fibrosis
hcc
hepatocellular carcinoma
lpa
lpar1
nash
non-alcoholic steatohepatitis
Online Access:http://dx.doi.org/10.1080/23723556.2017.1311827

Internet

http://dx.doi.org/10.1080/23723556.2017.1311827

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