Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain

Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain

2,6-di-tert-butylphenol (2,6-DTBP) ameliorates mechanical allodynia and thermal hyperalgesia produced by partial sciatic nerve ligation in mice, and selectively inhibits HCN1 channel gating. We hypothesized that the clinically utilized non-anesthetic dimerized congener of 2,6-DTBP, probucol (2,6-di-...

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Bibliographic Details
Main Authors: Rebecca L. Joyce, Gareth R. Tibbs, J. David Warren, Christopher J. Costa, Kelly Aromolaran, R. Lea Sanford, Olaf S. Andersen, Zhucui Li, Guoan Zhang, Dianna E. Willis, Peter A. Goldstein
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Neurobiology of Pain
Subjects:
Anti-hyperalgesia
Alkylphenol
HCN1
Ion channel
Spared nerve injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2452073X23000284

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http://www.sciencedirect.com/science/article/pii/S2452073X23000284

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