Probucol is anti-hyperalgesic in a mouse peripheral nerve injury model of neuropathic pain
2,6-di-tert-butylphenol (2,6-DTBP) ameliorates mechanical allodynia and thermal hyperalgesia produced by partial sciatic nerve ligation in mice, and selectively inhibits HCN1 channel gating. We hypothesized that the clinically utilized non-anesthetic dimerized congener of 2,6-DTBP, probucol (2,6-di-...
Main Authors: | Rebecca L. Joyce, Gareth R. Tibbs, J. David Warren, Christopher J. Costa, Kelly Aromolaran, R. Lea Sanford, Olaf S. Andersen, Zhucui Li, Guoan Zhang, Dianna E. Willis, Peter A. Goldstein |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-08-01
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Series: | Neurobiology of Pain |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2452073X23000284 |
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