Independent Cis-Regulatory Modules within the Herpes Simplex Virus 1 Infected Cell Protein 0 (ICP0) Promoter Are Transactivated by Krüppel-like Factor 15 and Glucocorticoid Receptor

Independent Cis-Regulatory Modules within the Herpes Simplex Virus 1 Infected Cell Protein 0 (ICP0) Promoter Are Transactivated by Krüppel-like Factor 15 and Glucocorticoid Receptor

A corticosteroid antagonist impairs Herpes Simplex Virus 1 (HSV-1) productive infection and explant-induced reactivation from latency, suggesting corticosteroids and the glucocorticoid receptor (GR) mediate certain aspects of these complex virus–host interactions. GR-hormone complexes regulate trans...

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Bibliographic Details
Main Authors: Nishani Wijesekera, Nicholas Hazell, Clinton Jones
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
herpes simplex virus type 1 (HSV-1)
infected cell protein 0 (ICP0) expression
stress
Krüppel-like factor 15
glucocorticoid receptor (GR)
Online Access:https://www.mdpi.com/1999-4915/14/6/1284

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https://www.mdpi.com/1999-4915/14/6/1284

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