β-(4-fluorobenzyl) Arteannuin B induced interaction of ATF-4 and C/EBPβ mediates the transition of breast cancer cells from autophagy to senescence

β-(4-fluorobenzyl) Arteannuin B induced interaction of ATF-4 and C/EBPβ mediates the transition of breast cancer cells from autophagy to senescence

ATF-4 is a master regulator of transcription of genes essential for cellular-adaptive function. In response to the quantum and duration of stress, ATF-4 diligently responds to both pro-apoptotic and pro-survival signals converging into either autophagy or apoptosis/senescence. Despite emerging cues...

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Bibliographic Details
Main Authors: Khalid Bashir Mir, Mir Mohd Faheem, Syed Mudabir Ahmad, Javeed Ur Rasool, Tanzeeba Amin, Souneek Chakraborty, Madhulika Bhagat, Zabeer Ahmed, Asif Ali, Anindya Goswami
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
arteannuin B
ATF-4
C/EBPβ
breast cancer
senescence
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1013500/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1013500/full

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