Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice

The <i>PSEN1</i> ΔE9 mutation causes a familial form of Alzheimer’s disease (AD) by shifting the processing of amyloid precursor protein (APP) towards the generation of highly amyloidogenic Aβ42 peptide. We have previously shown that the <i>PSEN1</i> ΔE9 mutation in human-ind...

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Bibliographic Details
Main Authors: Henna Jäntti, Minna Oksanen, Pinja Kettunen, Stella Manta, Lionel Mouledous, Hennariikka Koivisto, Johanna Ruuth, Kalevi Trontti, Hiramani Dhungana, Meike Keuters, Isabelle Weert, Marja Koskuvi, Iiris Hovatta, Anni-Maija Linden, Claire Rampon, Tarja Malm, Heikki Tanila, Jari Koistinaho, Taisia Rolova
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
Alzheimer’s disease
presenilin
iPSC
experimental transplantation
oligodendrocyte precursor cells
astrocytes
Online Access:https://www.mdpi.com/2073-4409/11/24/4116

Internet

https://www.mdpi.com/2073-4409/11/24/4116

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