Action Potential Prolongation, β-Adrenergic Stimulation, and Angiotensin II as Co-factors in Sarcoplasmic Reticulum Instability

Action Potential Prolongation, β-Adrenergic Stimulation, and Angiotensin II as Co-factors in Sarcoplasmic Reticulum Instability

Introduction: Increases in action potential duration (APD), genetic or acquired, and arrhythmias are often associated; nonetheless, the relationship between the two phenomena is inconstant, suggesting coexisting factors. β-adrenergic activation increases sarcoplasmic reticulum (SR) Ca2+-content; ang...

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Bibliographic Details
Main Authors: Carlotta Ronchi, Beatrice Badone, Joyce Bernardi, Antonio Zaza
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Physiology
Subjects:
action potential duration
angiotensin II
SR stability
arrhythmias
repolarization reserve
β-adrenergic activation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01893/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01893/full

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